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Hirschsprung's Disease Genetic Analysis Reveals Mix of Common, Rare Risk Variants
NEW YORK (GenomeWeb) – Genetic factors that contribute to a highly heritable developmental condition called Hirschsprung's disease include a complex suite of risk variants, ranging from common polymorphisms in non-coding elements to rarer coding variants and copy number variants (CNVs), according to new research from investigators at Johns Hopkins University, the University of Washington, the Broad Institute, and New York University.
"In our study, we found that the risk of the complex phenotype...
Correction to: Modulation of lipolysis and glycolysis pathways in cancer stem cells changed multipotentiality and differentiation capacity toward endothelial lineage
In the publication of this article [1], there is an error in one of the contributing author names.
The error: ‘Jalal Abdolali Zade’
Should instead read: ‘Jalal Abdolalizadeh’
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, prov...
Protein Expression: basic concepts to new directions
Date: Tuesday, 11 June, 2019
Time: 09:30 – 13:00
Place: Fèlix Serratosa, Parc Cientific de Barcelona (PCB)
This short workshop will describe many aspects of heterologous expression in E.coli, from choice of construct design through to methods to improve the levels of soluble expression and options for co-expression. In addition, it will also address expression in eukaryotic hosts, including secreted proteins and ECDs, and options for co-expression.
The workshop will finish with a discussion an...
Regulation of bacterial surface attachment by a network of sensory transduction proteins
http://orcid.org/0000-0002-8286-7219
http://orcid.org/0000-0002-0612-5029
http://orcid.org/0000-0002-1727-322X
Bacteria are often attached to surfaces in natural ecosystems. A surface-associated lifestyle can have advantages, but shifts in the physiochemical state of the environment may result in conditions in which attachment has a negative fitness impact. Therefore, bacter...
Study of Supercapacitive activity of Eu-MOF as an electrode material - New Journal of Chemistry (RSC Publishing)
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High surface area and redox activity are indispensable characteristics for a material to be considered as an electrode material in pseudocapacitors. In this regard, redox active metals-based metal-organic frameworks (MOFs) with high surface area, can function...
Chromosome-level de novo assembly of the pig-tailed macaque genome using linked-read sequencing and HiC proximity scaffolding
Old world monkey species share over 93% genome homology with humans and develop many disease phenotypes similar to those of humans, making them highly valuable animal models for the study of numerous human diseases. However, the quality of genome assembly and annotation for old world monkeys including macaque species lags behind the human genome effort. To close this gap and enhance functional genomics approaches, we employed a combination of de novo linked-read assembly and scaffolding using pr...
Tanshinone IIA induces apoptosis in fibroblast-like synoviocytes in rheumatoid arthritis via blockade of the cell cycle in the G2/M phase and a mitochondrial pathway.
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Mitochondria- and Oxidative Stress-Targeting Substances in Cognitive Decline-Related Disorders: From Molecular Mechanisms to Clinical Evidence
Copyright © 2019 Imane Lejri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Alzheimer’s disease (AD) is the most common form of dementia affecting people mainly in their sixth decade of life and at a higher age. It is an extensively studied neurodegenerative disorder yet incurable to date. While its main postmortem brain ha...
13 Best Images of Chromosomes And Genes Worksheet DNA and Replication Worksheet Answers, Gene
Wonderful 13 Best Images of Chromosomes And Genes WorksheetDNA and Replication Worksheet Answers, Gene
dna mutations practice worksheet answers - Learning regarding the actual value of money is among the primary lessons kids of today may learn. Most considerably you have to love them and you have to have `the present associated with teaching'. They are capable to draw an auto dvd unit of what they are reading through to assist them understand the problem.
You'll want to recognize, however, th...
Regulation of bacterial surface attachment by a network of sensory transduction proteins
http://orcid.org/0000-0002-8286-7219
http://orcid.org/0000-0002-0612-5029
http://orcid.org/0000-0002-1727-322X
Bacteria are often attached to surfaces in natural ecosystems. A surface-associated lifestyle can have advantages, but shifts in the physiochemical state of the environment may result in conditions in which attachment has a negative fitness impact. Therefore, bacter...