Active droplets for precise dosing of medication

Active droplets for precise dosing of medication

Bruker announces fully validated NMR module for metabolite quantification in urine (research use only) However, the oily shield is not entirely impermeable: Some of the oil molecules react with the surrounding water. This hydrolysis causes the droplets to slowly but continuously lose mass and shrink until they eventually disappear. "The constant decay of these 'active droplets', led us to the idea of using them to dose drugs," recalls Boekhoven. Safe from over- or underdosing Pharmacologists have long sought methods for administering active agents at a constant rate. The ingredients in ointments or tablets are usually released quickly, increasing the risk of an overdose. Moreover, the fast rate of release shortens the duration of the intended effect. Methods for releasing drugs over extended periods of time at a constant rate are rare and often complicated to fabricate. We found that the droplets continuously release the drug while they get smaller and smaller. The consequence is that over the entire release period, the drug release rate remains constant. The power of this approach lies in its simplicity. You need only three components: droplets made of a hydrolyzable oil, a drug that partitions in the oil, and a hydrogel that stabilizes the position of the droplets." Prof. Job Boekhoven, Technical University of Munich Many fields of application The new oil-hydrogel mix allows active agents to be administered not only continuously but also at a predetermined rate. The droplets can be loaded with larger or smaller doses of active substances. These are released as soon as the oil droplets come into contact with the water in blood or tissue. The hydrolysis proceeds at a constant rate until the droplets have dissipated completely. These "active droplets" have many potential fields of application. They could, for example, be deployed in disinfectant or healing-promoting sore pads to treat poorly healing wounds. A patent application has already been filed for the oil-hydrogel material. Source: Technical University of Munich (TUM) Journal reference: Wanzke, C., et al. (2020) Active droplets in a hydrogel release drugs with a constant and tunable rate. Materials Horizons. doi.org/10.1039/C9MH01822K .



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