AI VIVO, the Cambridge based company combining systems pharmacology and artificial intelligence (AI) to accelerate drug discovery, has announced that it is seeking pharma and biotech collaboration partners to progress therapeutic candidates that have been identified by the Company as “top-ranked” for COVID-19. The announcement follows the finding that 41 of the candidate drugs from AI VIVO’s top-ranked list for COVID-19 are now in clinical trials for COVID-19 by multiple groups globally. Dr Peyman Gifani, AI VIVO founder and CEO
This underlines the ability of AI VIVO’s platform to systematically and correctly identify candidates with the highest chance of therapeutic success. AI VIVO is now seeking partners to test other candidates identified by the platform as top-ranked, which provide anti-viral, anti-inflammatory and cytokine storm suppressive effects. Using its unique technology, the company also compiled a list of drug combinations from its top-ranked list and they are keen to share the results with pharma companies and clinical trial investigators.
On 06 April 2020, AI VIVO announced that its systems pharmacology platform, which is powered by AI, had identified several candidate drugs that are highly likely to be effective in treating the disease. At that time, five drug candidates from their top ranked list had already been selected by other groups for COVID-19 clinical trials. In less than a month, the number of compound candidates from AI VIVO’s top ranked list that are registered for COVID-19 clinical trials has grown from five to 41 candidates.
This overlap is significant because AI VIVO’s ranking system is based on the Company’s unique phenotypic drug discovery methodology and does not rely on any prior knowledge or known information related to the disease or compounds. To identify the candidate drugs most likely to be effective in treating the disease, AI VIVO used samples from COVID-19 infected cells to build its model for the disease, which was then used to rank 90,000 compounds. The top candidate compounds list represents only 0.3% of the evaluated drugs. Related Stories
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