AMP publishes evidence-based recommendations to standardize clinical genotyping tests for warfarin response

AMP publishes evidence-based recommendations to standardize clinical genotyping tests for warfarin response

The Association for Molecular Pathology (AMP), the premier global, molecular diagnostic professional society, today published consensus, evidence-based recommendations to aid in the design, validation and interpretation of clinical genotyping tests for the prediction of warfarin response. The manuscript, "Recommendations for Clinical Warfarin Sensitivity Genotyping Allele Selection: A Joint Recommendation of the Association for Molecular Pathology and College of American Pathologists," was released online ahead of publication in The Journal of Molecular Diagnostics . The new guideline on clinical warfarin sensitivity genotyping allele selection completes a series of three reports that were intended to facilitate testing and promote standardization for frequently used pharmacogenetics (PGx) genotyping assays. Developed by the AMP PGx Working Group with organizational representation from the College of American Pathologists (CAP) and the Clinical Pharmacogenetics Implementation Consortium (CPIC), the latest report builds on the earlier recommendations for clinical CYP2C19 and CYP2C9 genotyping. The recommendations should be implemented together with other clinical guidelines such as those issued by the CPIC, which focus primarily on the interpretation of PGx test results and therapeutic recommendations for specific drug-gene pairs. Clinical genotyping assays that help predict warfarin response and optimize a patient's dosage requirements have enabled some of the earliest success stories of this precision medicine era. Together, the AMP PGx Working Group defined a standard set of evidence-based recommendations that will help build on these past successes and improve phenotype prediction and test interpretation for all future warfarin sensitivity genotyping panels." Victoria M. Pratt, PhD, FACMG, Professor and Director of Pharmacogenetics and Molecular Genetics Laboratories, Indiana University School of Medicine, and AMP PGx Working Group Chai Related Stories



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