Antiplatelet medication used to treat leg pain may prevent re-blockage of carotid artery stents

Antiplatelet medication used to treat leg pain may prevent re-blockage of carotid artery stents

Study explains “Swiss-cheese” bones suspected to cause lower back pain The Carotid Artery Stenting with Cilostazol Addition for Restenosis (CAS-CARE) study is a multi-center, prospective, randomized, open-label trial evaluating the inhibitory effect of cilostazol on in-stent restenosis, compared to other antiplatelet medications in patients scheduled to undergo carotid artery stenting. Eligible patients were randomly assigned to receive cilostazol (50 mg or 100 mg, twice per day), or any antiplatelet agents other than cilostazol, starting three days before stenting and continued for two years. A total of 631 patients (average age 70, 88% men) were included in the full study analysis. In-stent restenosis occurred in 9.5% patients in the cilostazol group and 15% of patients in the non-cilostazol group during two years of follow-up. The rate of cardiovascular event occurrence was about 6% in both groups. Bleeding events were also similar for both groups at 1.1% in those treated with cilostazol vs. 0.3% among those not treated with cilostazol. The list of study authors and disclosures are available in the abstract. CAS-CARE was funded by Translational Research Center for Medical Innovation (TRI), a public interest foundation. TRI raised financial resources for conducting research, and Otsuka Pharmaceutical Co., Ltd. donated research funds. Otsuka Pharmaceutical was not involved in any study activities, such as planning or conducting research, collecting data and analyzing results. Some of the investigators have received a grant from Otsuka Pharmaceutical for works not related to this research and have no financial relationship regarding CAS-CARE. Source:



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