SARS-CoV-2 genome shows mutation hotspots and type-specific distribution
Whilst initial trials of the screening process have been successful, the collaborators now need to engage with other companies and research centers to screen infectious serum samples. This is a specialized diagnostic field and by joining efforts within the global life sciences community, Arrayjet and CDI will further advance the roll-out of their program.
Arrayjet’s technology ArrayPlex, can reveal if a person has an antibody signature in their blood which indicates that they have already been exposed to SARS-Cov-2.
ArrayPlex is a high-throughput library screening application which was originally developed to find immunotherapy drugs for cancer. For the COVID-19 trials, ArrayPlex has been adapted and repurposed to allow 18,000 patient serum samples in one ‘library’ to be screened against a small protein library from the COVID-19 virus, SARS -Cov-2. Each week the platform will generate 1 ¼ million separate datapoints describing the immune profiles of 126,000 patients. This high-volume capacity to process population-scale samples is what makes this technique a ground-breaking achievement in the quest against COVID-19.
Screening 18000 patients in a 24-hour period is a considerable achievement but it’s a figure that is readily manageable with this technology. We are dealing with an extremely virulent strain of coronavirus, so it is important that the process is highly automated to reduce the risks of technical teams coming into contact with infectious samples.” Iain McWilliam
Coronaviruses tend to induce weak immune responses, which means secondary infections of COVID-19 remain a distinct possibility, and therefore managing COVID-19 is a long-term problem. Arrayjet and CDI, with their Arrayplex COVID-19 antibody screening solution, are offering an innovative contribution to these challenges. Source:
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