Johns Hopkins researchers make progress in the development of noninvasive urine test for prostate cancer
Using data from 15 large studies combined together, Genkinger examined associations between body fat, height, and prostate cancer risk in 830,772 men, 51,734 of whom had been diagnosed with prostate cancer. Her study took a life-course-based approach, examining survey data collected across respondents' lifespans to determine whether and at what age during adulthood excess body fat increased risk for advanced prostate cancer. The researchers found that a BMI elevated above a healthy weight during middle to late adulthood--median age range from 50 to 64--was linked to the greatest risk for developing advanced prostate cancer. A "healthy" weight is defined as a BMI between 21 and 25 kg/m2.
They also found that greater waist circumference was linked with increased risk of advanced prostate cancer and death. Although other studies have linked higher BMI with increased prostate cancer, this is the first study to find a positive association with waist circumference.
These study results show that risk for advanced prostate cancer can be decreased by maintaining a 'healthy' weight, which is in line with guidelines by the American Cancer Society and World Cancer Research Fund. Adopting healthy eating and exercising are factors that can help maintain a healthy weight. This study shows that adopting and maintaining healthy weight in middle to late adulthood can especially reduce risk of advanced prostate cancer." Jeanine Genkinger, associate professor of epidemiology at Columbia Mailman School Source:
Columbia University's Mailman School of Public Health Journal reference:
Genkinger, J.M., et al. (2020) Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer: risk and mortality in The Pooling Project of Prospective Studies of Diet and Cancer. Annals of Oncology . doi.org/10.1016/j.annonc.2019.09.007 .
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