Clinical trial to evaluate experimental COVID-19 drug is underway at Montefiore and Einstein

Clinical trial to evaluate experimental COVID-19 drug is underway at Montefiore and Einstein

Beards and COVID-19 in the healthcare setting The randomized, double-blind, placebo-controlled trial is being led by principal investigator Barry Zingman, M.D., professor of medicine at Einstein and clinical director, infectious diseases, in the Moses division of Montefiore Health System. The trial is "adaptive," meaning it can be modified to include other investigational treatments. "This flexibility allows us to add additional therapies to the trial step-by-step to improve treatment as the pandemic continues," said Dr. Zingman. Trial participants are hospitalized patients with a laboratory-confirmed coronavirus infection and lung complications, including rattling sounds when breathing, a need for supplemental oxygen, abnormal chest X-rays showing pneumonia, or the need for a mechanical ventilator. People in the treatment group will receive 200 mg of remdesivir intravenously on the first day of their enrollment in the study and will receive another 100 mg each day for the duration of hospitalization, for up to 10 days total. The placebo group will receive an equal volume of a solution that resembles remdesivir but contains inactive ingredients. Montefiore and Einstein's robust clinical trial infrastructure contributed to its selection and rapid approval for participation. No therapies have yet been approved by the U.S. Food and Drug Administration for treating COVID-19. Remdesivir, an investigational antiviral therapy, was developed by Gilead Sciences, Inc. Source:



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