ERA-EDTA creates European database of dialysis, transplanted patients with COVID-19

ERA-EDTA creates European database of dialysis, transplanted patients with COVID-19

The ERA-EDTA has created a European database that collects granular individual data of dialysis patients and transplanted patients with COVID-19. "End stage renal disease patients are generally assumed to be at very high risk of experiencing severe COVID-19 complications. In triage processes, therefore, they are sometimes refused admission to intensive care units. However, there are conflicting data from individual clinicians that suggest that COVID-19 have limited symptomatology in patients on dialysis or with a kidney transplant. This is why we need to collect detailed data", explains ERA-EDTA Press Officer, Professor Ron Gansevoort. "Our hope is to gain insights into the patient and treatment characteristics that are related to outcome and to learn about modifiable risk factors, which would help to improve the prognosis of our patients." So far, the database on COVID-19 disease progression in patients on renal replacement therapy is very limited. There are some singular case reports from China and Italy, but prevalence and outcomes are highly heterogeneous. One center in Wuhan reported that 37 out of 230 patients had been infected, six of whom died. This points to a mortality rate of 16%. In a center in Lombardy, 18 patients were infected, and only one was in critical condition. A first (unpublished) analysis performed ten days after the launch of a Spanish registry showed a mortality rate of 44% in hemodialysis patients, which would be an upsettingly high number. "But several biases might have interfered. First of all, the data might be highly selective after ten days in the midst of the crisis. Nephrologists are very busy these days, so many doctors might mainly have registered those patients who had died, but not the ones who had recovered or were still struggling with the disease. Furthermore, Spain has the highest transplantation level in Europe, which means that Spanish patients on dialysis are indeed particularly frail and old and cannot be compared to the dialysis population of other countries where organ transplantation rates are much lower", explains the expert. Related Stories



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