Free radicals from immune cells linked to salt-sensitive hypertension

Free radicals from immune cells linked to salt-sensitive hypertension

Powerful vaccine could boost the effectiveness of cancer immunotherapy A high-salt diet fed to normal rats doesn't cause hypertension or that clustering of immune cells. Postmortem studies of humans who died from all causes indicated those with hypertension also had more immune cells in their kidneys along with increased kidney damage. Now they are working to learn more about precisely what the free radicals the immune cells produce are doing and they think its several bad things For this study, the scientists wanted to know why the immune cells move into the kidneys and what they are doing when they get there. Based on what they and others already had seen, they reasoned they could be producing ROS. In terms of the true instigator, some theorize an errant immune system also is the culprit, driving up pressure a bit initially, and causing damage that attracts the army of ROS-producing immune cells. Mattson's lab theorizes and has evidence that the problem actually starts with kidneys that do not eliminate salt sufficiently, which means fluid levels increase and so does pressure. While it may be sound advice for all of us to lighten up on the salt, our kidneys will eliminate excess salt for most us. But in about half of people with hypertension, salt is a major driver and there are not currently tests to easily diagnose it or drugs that target this pervasive problem, Mattson says. "All of us have all kinds of salts in our body and we need it to hold onto water, "Mattson says. "It's only in maybe the last 50 years or so when we adapted to this Western, modern lifestyle where we are consuming excess salt that this becomes a problem. "With a little bit of a pressure increase, you can go on a low-salt diet or eat more potassium or fresh vegetables, and probably bring your blood pressure down," Mattson adds. "But if you have your immune system fully activated, the disease is amplified and I think that is where we get into trouble." There are a lot of high-salt culprits besides French fries, like frozen dinners and prepackaged foods, canned vegetables, packaged deli meat even some of our favorite condiments like ketchup. So while a low-salt diet may be helpful, it also may be harder than you think, they say. There is evidence that suppressing the immune system can lower blood pressure but the scientists say that likely is not a smart or safe way to tackle the problem. While they are working on both a test and targeted therapies for salt-sensitive hypertension, right now, determining salt sensitivity is essentially anecdotal when, in first steps to lower blood pressure, people find that dietary modifications, like eating less canned and processed foods, really start to work. "If you change your dietary habits and blood pressure comes down that would be a clue you have salt-sensitive hypertension," Mattson says. The scientists also note that as with many diseases, there are both genetic and environmental factors that contribute to hypertension. Our fist-sized kidneys filter about a half cup of blood every minute, and are critical to maintaining a healthy fluid balance in the body, a blood pressure that ensures adequate blood and oxygen delivery bodywide, and eliminating things we don't need like excessive salt, while resorbing things we do. About 46% of white adults and 54% of black adults have high blood pressure, according to the Centers for Disease Control and Prevention, and an estimated 1 in 5 adults are unaware they have it. Among those recommended to take medication, about 32% of white and 25% of black adults have control. "If you just walk outside, you will see somebody who has this going on inside," Mattson says of the pervasive health problem. "It shortens their life." Source:



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