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The researchers then cut these sheets to form yarn - a bit like that used to make fabric for clothing. "The resulting yarn can be woven, knitted or braided into various forms. Our main objective is to use this yarn to make assemblies which can replace the damaged blood vessels", adds L'Heureux.
Made entirely from biological material, these blood vessels would also have the advantage of being well-tolerated by all patients. Given that collagen does not vary from individual to individual, it is not expected that the body will consider these vessels as foreign bodies that need to be rejected.
The researchers would now like to refine their techniques used to produce these "human textiles" before moving on to animal testing, in order to validate this last hypothesis. If these are conclusive, this could lead to clinical trials. Source:
INSERM (Institut national de la santé et de la recherche médicale) Journal reference:
Magnan, L., et al. (2020) Human textiles: A cell-synthesized yarn as a truly “bio” material for tissue engineering applications. Acta Biomaterialia . doi.org/10.1016/j.actbio.2020.01.037 .
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