Patients using copper IUDs have lower cervical cancer risk compared to LNG-IUS users
The majority of patients present with early-stage prostate cancer and choose active surveillance (where they are monitored with prostate-specific antigen (PSA) testing and follow-up biopsies) over immediate treatment with surgery or radiation. However, at least one-third of these patients experience disease progression or undergo definitive treatment within two years of follow-up.
Interventions that prevent disease progression would decrease the need for treatment and improve the quality of life among these patients and diet modification represents one potential approach to achieving this. What did the current study involve?
To investigate whether a behavioral intervention designed to increase micronutrient-enriched vegetable intake among men with early-stage prostate cancer was effective at preventing disease progression, Parsons and team conducted a phase 3 study called The Men’s Eating and Living (MEAL) Study.
This randomized clinical trial was conducted at 91 urology and medical oncology clinics and involved 478 men, aged 50 to 80 years, diagnosed with early-stage prostate adenocarcinoma, who were on active surveillance.
Patients were randomly assigned to receive a motivational telephone-based behavioral counseling encouraging consumption of at least 7 daily servings of vegetables (intervention group, n=237) or written information about diet and prostate cancer (control group, n= 241.)
The men were enrolled between January 2011 to August 2015 and were followed up over two years from January 2013 to August 2017. The findings failed to support the use of the intervention
As reported in JAMA , the intervention did produce robust and sustained increases in the men’s consumption of carotenoid-, cruciferous-rich and leafy green vegetable for two years. However, there was no significant difference in time-to-disease-progression between the intervention and control groups.
“These data fail to support prevailing assertions in evidence-based clinical guidelines and the popular media that diets high in micronutrient-enriched vegetables improve cancer-specific outcomes among prostate cancer survivors,” writes the team.
“The findings do not support the use of this intervention to decrease prostate cancer progression in this population,” they conclude. Sources:
Did increasing vegetable consumption reduce the risk of prostate cancer progression? Eurekalert 2020. Available at: https://www.eurekalert.org/login.php?frompage=/emb_releases/2020-01/jn-div010920.php
What foods should I eat or avoid if I have prostate cancer? Prostate Cancer UK 2018. Available at: https://prostatecanceruk.org/prostate-information/living-with-prostate-cancer/your-diet-and-physical-activity/foods-to-eat-or-avoid Journal reference:
Parsons JK, et al. Effect of a Behavioral Intervention to Increase Vegetable Consumption on Cancer Progression Among Men with Early-Stage Prostate Cancer The MEAL Randomized Clinical Trial JAMA 2020;323(2):140-148. DOI:10.1001/jama.2019.20207
Also in Industry News
How to decide whether or not to start treatment for prostate cancer?
Analysis of the SARS-CoV-2 proteome via visual tools
$65m investment increases British Patient Capital’s exposure to life sciences and health technology