New nanoparticle innovation detects vascular calcification in atherosclerosis
The team was led by Ana Alcudia Cruz, of the Department of Organic and Pharmaceutical Chemistry from the Pharmacy faculty at the University of Seville, in collaboration of the group led by Rafael Prado Gotor of the Department of Physical Chemistry, from the Chemistry Faculty at the University of Seville, and Ricky Wilman, from the University of Nottingham (United Kingdom). For the first time, it managed to use polymers (polyurethanes) with a comb structure, which they themselves developed, to generate tiny gold nanoparticles with extremely high stability that was tested over time.
To that end, various polymers were prepared from arabinose, a sugar that is easily acquired in nature and that gives the material developed total biocompatibility and biodegradability, so avoiding polluting residues generated by the traditional polymers that are oil-derived.
For the first time this type of polymer has been used for the preparation of gold nanoparticles. These nanoparticles, obtained from three different chemically functionalized polymers, proved to be sufficiently small (maximum 10nm) to be printed in Inkjet printing and were stable for a period of at least six months. Once the printability of each ink was tested, that which showed the best balance of properties was selected and used to print the logo of our university. In the image, obtained by TOF-SIMS, the gold can be observed (in yellow), which forms the outline of the logo, on a polymer background (in blue). This is the first image of gold nanoparticles stabilized with biodegradable and biocompatible systems that has been obtained with 3D-printng techniques. Source:
University of Seville Journal reference:
Begines, B., et al. (2019) Design of highly stabilized nanocomposite inks based on biodegradable polymer-matrix and gold nanoparticles for Inkjet Printing. Scientific Reports . doi.org/10.1038/s41598-019-52314-2 .
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