New method for detection of microcystins and nodularin in human urine

New method for detection of microcystins and nodularin in human urine

Aspirin’s benefits may extend beyond heart health to colorectal cancer treatment Results of the study, published in the journal Toxins , demonstrate that the IC-PPIA method developed by the CDC was able to detect low-dose human exposures to microcystins by analysis of urine from three of the 86 urine specimens analyzed by this new method, which yielded positive results with concentrations of 0.055, 0.089 and 0.052 ng/mL MC-LR equivalents. These findings are the first to report microcystin concentrations directly from exposed residents impacted by cyanobacteria in Florida. This new test can detect even low-dose human exposure to microcystins and nodularin, so this method will be important as we study the long-term health impacts of harmful algal blooms, especially the low-level concentrations from human inhalation exposure. This method could complement water monitoring programs by identifying human exposures to these toxins at the time of harmful algal blooms and will assist our ongoing research to elucidating health effects associated with these algal blooms. This research is a critical step in developing and interpreting clinical diagnostic tests for harmful algal bloom exposure around the world." Adam Schaefer, MPH, co-author and epidemiologist at FAU's Harbor Branch To assess human exposure to microcystins during the 2018 algal blooms, Schaefer and faculty and collaborators from FAU's Christine E. Lynn College of Nursing, collected urine, nasal swabs and blood from residents of St. Lucie, Indian River, Palm Beach and Martin counties as a part of a cross-sectional exposure study. A comprehensive questionnaire that included questions on potential routes of exposure to the blooms, fish consumption, and demographic data was administered at the time of sample collection. Source: Florida Atlantic University Journal reference: Wharton, R. E., et al. (2019) Measurement of Microcystin and Nodularin Activity in Human Urine by Immunocapture-Protein Phosphatase 2A Assay. Toxins . doi.org/10.3390/toxins11120729 .



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