Researchers propose aspirin as possible treatment option for patients with migraine
"This change especially makes sense for us because the majority of our patient population is considered at-risk," Blackwell said. "There is a very low cost and risk associated with this therapy, and we hope a universal approach minimizes missed opportunities for treatment at a population level."
The routine use of low-dose aspirin could also reduce rates of other adverse pregnancy outcomes, such as preterm birth and fetal growth restriction, while only costing less than $10 per pregnancy, Sibai said.
"Most patients are amenable once they understand what preeclampsia is and how serious it is. The dose is so small and there's really no side effects, so most patients are fine with adding it to their prenatal vitamin. For perspective, people taking daily aspirin for heart attack are recommended to take 325 mg, about four times the 81 mg we're recommending," Ankumah said.
Under this recommendation, low-dose aspirin is recommended beginning at 12 weeks and continued through delivery. According to ACOG, there is no increased risk of postpartum bleeding or placental abruption. Exclusions include women with allergies to nonsteroidal anti-inflammatory drugs and women with vaginal bleeding.
"This is a major paradigm shift in prenatal care and is just another way we are incorporating several novel aspects to care to provide cutting-edge, evidence-based treatments to our patients," Blackwell said.
Researchers at UTHealth are also investigating how to prevent postpartum hypertension. A recent study led by Conisha Holloman, MD, a maternal-fetal medicine fellow with McGovern Medical School, suggests that all women should be informed about the symptoms of high blood pressure, also known as postpartum hypertension.
The study, published in the American Journal of Obstetrics and Gynecology , looked at 164 women from September 2016 to July 2019 who gave birth at Children's Memorial Hermann Hospital in Houston and were readmitted with high blood pressure. More than 64% of women were readmitted within seven days, and 39% of those women were not diagnosed with high blood pressure prior to being discharged.
"Texas has one of the highest maternal mortality rates in the nation. As clinicians, we're always looking for ways to tailor interventions so we can reduce deaths," Holloman said. "While clearly more research needs to be done on what causes high blood pressure after childbirth, what our study reveals is a strong need to educate all women, not just those who may be at a higher risk, about the signs and symptoms of high blood pressure before they are discharged." Source:
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