'Pulling the plug' on calcium pumps to kill pancreatic cancer cells

'Pulling the plug' on calcium pumps to kill pancreatic cancer cells

UK scientists have identified a new way to kill pancreatic cancer cells by 'pulling the plug' on the energy generator that fuels calcium pumps on their cell surface. The study, published in the British Journal of Cancer , reports how switching off the cancer's energy supply causes the pancreatic cancer cells to become 'poisoned' by an irreversible build-up of calcium. Calcium inside cells is normally beneficial as it controls numerous cell functions. However, calcium levels are tightly controlled and normally kept at very low levels, as prolonged elevations in calcium lead to cell death. This tight control is achieved by calcium pumps on the cell surface that use chemical energy to pump calcium out of the cell. The researchers discovered that switching off the cancer cells' energy supply causes these pumps to fail and calcium to rise, much like a damaged boat taking on water. Dr Jason Bruce, from the Division of Cancer Sciences at the University of Manchester, who led the research, said: Pancreatic cancer has some of the worst survival statistics and is notoriously resistant to standard treatments. Therefore, identifying potential weaknesses of pancreatic cancer cells that could be exploited to selectively kill them - essentially finding their 'Achilles Heel' - must remain a central research strategy if we are to tackle this devastating disease." The research, funded by the UK charity Pancreatic Cancer Research Fund, identified that pancreatic cancer cells have a unique way of extracting energy from sugar to fuel their calcium pumps. They use a specific enzyme, called PKM2, which the researchers found in high levels in tumours compared to surrounding healthy tissue of patients with pancreatic cancer. They also found that the amount of PKM2 in tumours correlated with poor patient survival, suggesting this could be targeted to treat pancreatic cancer. Related Stories



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