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Scientists have identified certain factors (social, environmental and lifestyle factors) that contribute to systemic chronic inflammation. Taken together, such factors are the main cause of disability and mortality worldwide.
Some of the most powerful tools in research of aging processes are genomic, transcriptomic and proteomic analyses (collectively referred to as "omics"). However, although the trajectory of human aging can be established as early as at the moment of fetal development in the womb, the factors influencing the whole life cycle also have a strong influence. Professor Franceschi insists that the lifestyle, the effects of stressors, the history of vaccinations, as well as the social and cultural characteristics of each individual starting from the first days of life to adulthood should be determined in as much detail as possible and taken into account.
An integrative approach to the study of mechanisms of systemic chronic inflammation is being adopted by a growing number of scientists. Research is continuing, and scientists have a long way to go to fully understand the role of chronic inflammation in aging and mortality, and to be able to predict changes in a person's health throughout life.
Research results open up new strategies for early diagnosis, prevention and treatment of a wide range of diseases associated with systemic chronic inflammation. It is expected that prevention and treatment of inflammatory processes will serve to slow down aging and prolong life.
Under the guidance of Professor Franceschi, the megagrant project "Digital Personalized Medicine for Healthy Aging" is being implemented at the Lobachevsky University of Nizhny Novgorod where a unique Center for Healthy Aging and Active Longevity has been established with the aim of making a breakthrough in the search for aging markers, early diagnosis of age-related diseases and, ultimately, achieving active longevity. Source:
Lobachevsky University Journal reference:
Furman, D., et al. (2019) Chronic inflammation in the etiology of disease across the life span. Nature Medicine . doi.org/10.1038/s41591-019-0675-0 .
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