DSB structure impacts DNA recombination leading to class switching and chromosomal translocations in human B cells

DSB structure impacts DNA recombination leading to class switching and chromosomal translocations in human B cells

May 08, 2019 0 Comments

http://orcid.org/0000-0001-8627-1167 http://orcid.org/0000-0002-1260-7710 Class switch recombination (CSR) requires activation-induced cytidine deaminase (AID) to trigger DNA double strand breaks (DSBs) at the immunoglobulin heavy chain (IGH) in B cells. Joining of AID-dependent DSBs within IGH facilitate CSR and effective humoral immunity, but ligation to DSBs in non-IGH chromosomes leads to chromosomal translocat...

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