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The team hypothesized that the particles could be used as "molecular sieves" in the intestine to trap and block digestive enzymes that break down food and thus reduce the energy uptake into the body (measured as food efficiency).
In the study reported in Nanomedicine , mice were fed high fat, high calorific diets, to induce weight gain, mixed with specially engineered MSPs. The results showed that MSPs reduced food efficiency by 33 percent leading to a lower weight gain, and a positive effect on the metabolic profile, as well as significant lower levels of adipose tissue formation and leptin, together with lower levels of circulating insulin.
"The data presented in this study suggest that tailored MSPs could be used to treat obesity and diabetes in humans, especially when taking into account their excellent safety profiles. Since we completed this work, clinical trials have been devised and are now underway," says professor Tore Bengtsson. Source:
Stockholm University Journal reference:
Rinde, M. et al . (2020) Mesoporous silica with precisely controlled pores reduces food efficiency and suppresses weight gain in mice. Nanomedicine . doi.org/10.2217/nnm-2019-0262
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