Brain tumor 'GPS' maps soon be tested in clinical trials
Cancer cells often increase their expression to "trick" the immune system and avoiding being detected as foreign or harmful and thus avoid being attacked or destroyed. Manipulating c-Cbl's ability to regulate expression of PD-1 may be incredibly beneficial in the treatment of these cancers.
Researchers examined the effect of c-Cbl on immune cells on experimental models lacking one copy of the c-Cbl gene. Tumor cells were implanted in these models and growth of the tumors was compared between models lacking the gene and unmodified models which served as controls. The researchers found that tumor growth was greater in the genetically the modified model.
According to the researchers, it may be possible in the near future to develop therapies that will inhibit tumor growth by activating c-Cbl protein.
While drugs targeting PD-1 are currently available for clinical use and such agents command a global market cap of more than $3 billion, only a small fraction of cancer patients respond to them. This trend suggests a need for agents that work simultaneously on more than one cancer-causing mechanism. Activating c-Cbl will degrade several proteins that contribute to tumor formation allowing the effects of its actions to go above and beyond PD-1 medications alone." Vipul Chitalia, MD, PhD, corresponding author, associate professor of medicine at BUSM
These findings appear online in the journal Scientific Reports . Source:
Boston University School of Medicine Journal reference:
Lyle, C., et al. (2019) c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth. Scientific Reports . doi.org/10.1038/s41598-019-56208-1 .
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