Premature babies with bronchopulmonary dysplasia have more stem cells at birth
The Functional Cytomics Research Group at the Josep Carreras Leukaemia Research Institute has developed innovative trials that allow the identification of these cells by testing the activity of a protein, alkaline phosphatase, present in myeloblasts.
To do this, they have used advanced cytomical methodologies that allow multiple functional characteristics to be analyzed cell by cell, individually, in a very few minutes.
The researchers identified a group of patients whose leukemic cells had high levels of alkaline phosphatase activity and another group of patients with lower levels of this activity. Both groups showed a differential response to chemotherapy treatment, with the most active phosphatase group showing the worst reaction to treatment and the shortest survival. Surprisingly, no significant association was detected between the results obtained through different cytogenetic analysis techniques and molecular studies, with the determination of prognostic factors of greater or lesser risk.
These results represent a new approach to improve the prognosis in the diagnostic evaluation of acute myeloid leukemia and to estimate the probability of relapse and persistence of the disease. This will allow us to open new lines of research aimed at applying alternative strategies in terms of treatment." Dr. Jordi Petriz, director of the study Source:
Josep Carreras Leukaemia Research Institute Journal reference:
Rico, L.G., et al. (2019) Flow cytometric significance of cellular alkaline phosphatase activity in acute myeloid leukemia. Oncotarget . doi.org/10.18632/oncotarget.27356 .
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