Tau-protein better predicts brain atrophy in Alzheimer's patients than amyloid plaques
Recent studies have shown a developmental program that drives the disproportionate thickening of L2/3 - a unique characteristic that may be fundamental to what makes us human. Albert Gidon and colleagues used somato-dendritic patch clamp and two-photon imaging to directly probe the active properties of L2/3 dendrites in slices of human brain tissue. The investigation revealed several previously unidentified electrical properties unique to L2/3 neurons unknown in all other neurons studied to date. Gidon et al. also identified a new class of dendritic calcium action potentials (dCaAPs).
The findings make the activity of L2/3 dendrites far more complex than previously thought, according to the authors. By modeling their properties, the authors demonstrate the ability of single neurons to solve computational problems that were previously thought to require multi-layer neural networks. Source:
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