Exposure to ozone pollution or wood smoke exacerbates lung disease in former and current smokers
The new study performed by the CHAI Project, led by ISGlobal and published in Jama Network Open , analyzed the association between air pollution and bone health in over 3,700 people from 28 villages outside the city of Hyberabad, in southern India.
The authors used a locally-developed model to estimate outdoor exposure at residence to air pollution by fine particulate matter (suspended particles with a diameter of 2.5 μm or less) and black carbon. The participants also filled a questionnaire on the type of fuel used for cooking. The authors linked this information with bone health assessed using a special type of radiography that measures bone density, called dual-energy x-ray absorptiometry, and measured bone mass at the lumbar spine and the left hip.
The results showed that exposure to ambient air pollution, particularly to fine particles, was associated with lower levels of bone mass. No correlation was found with use of biomass fuel for cooking.
"This study contributes to the limited and inconclusive literature on air pollution and bone health," explains Otavio T. Ranzani, ISGlobal researcher and first author of the study. Regarding the possible mechanisms underlying this association, he says "inhalation of polluting particles could lead to bone mass loss through the oxidative stress and inflammation caused by air pollution".
Annual average exposure to ambient PM2.5 was 32.8 μg/m3, far above the maximum levels recommended by the World Health Organisation (10 μg/m3). 58% of participants used biomass fuel for cooking.
Our findings add to a growing body of evidence that indicates that particulate air pollution is relevant for bone health across a wide range of air pollution levels, including levels found in high income and low-and medium-income countries." Cathryn Tonne, coordinator of the study and of the CHAI project Source:
Barcelona Institute for Global Health (ISGlobal) Journal reference:
Ranzani, O.T., et al. (2020) Ambient and Household Air Pollution and Bone Mineral Content Among Adults in Peri-urban South India. Jama Network Open . doi.org/10.1001/jamanetworkopen.2019.18504 .
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