Study shows how the immune system achieves antibody diversity
The collaborative groups, including researchers at Exploratory Research Center on Life and Living Systems (ExCELLS) and Institute for Molecular Science (IMS) of National Institutes of Natural Sciences and Graduate School of Pharmaceutical Sciences of Nagoya City University investigated this mechanism utilizing high-speed atomic force microscopy. They successfully visualized the dynamic process by which the autoantibodies that are bound to GM1 contained in membranes spontaneously assemble to form a hexameric ring structure on the membrane. They also revealed that the assembled antibodies serve as a landing place for the first charge commander C1q on the membrane, which is the initial step of complement-mediated cell lysis. The groups' findings will provide deep insights into the molecular mechanisms behind Guillain-Barré syndrome and offer clues for controlling antibody assembly and consequent complement activation. Source:
National Institutes of Natural Sciences Journal reference:
Yanaka, S., et al. (2020) On-Membrane Dynamic Interplay between Anti-GM1 IgG Antibodies and Complement Component C1q. International Journal of Molecular Sciences . doi.org/10.3390/ijms21010147 .
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