The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma

The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma

IJMS | Free Full-Text | The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma Next Article in Journal New Innovations in Wound Healing and Repair Previous Article in Journal Crude α-Mangostin Suppresses the Development of Atherosclerotic Lesions in Apoe-Deficient Mice by a Possible M2 Macrophage-Mediated Mechanism Previous Article in Special Issue Molecular Mechanisms of Pulmonary Fibrogenesis and Its Progression to Lung Cancer: A Review Choose your preferred view mode Please select whether you prefer to view the MDPI pages with a view tailored for mobile displays or to view the MDPI pages in the normal scrollable desktop version. This selection will be stored into your cookies and used automatically in next visits. You can also change the view style at any point from the main header when using the pages with your mobile device. Use mobile version Use desktop version Menu Search MDPI — IJMS IJMS Log in MDPI Journals A–Z Information & Guidelines For Authors For Reviewers For Editors For Librarians For Publishers For Societies Article Processing Charges Open Access Policy Institutional Open Access Program Editorial Process English Editing Service MDPI Blog Initiatives Sciforum Preprints Scilit MDPI Books Encyclopedia About Login Register Submit Switch to Desktop Version Close Menu MDPI Journals A–Z Information & Guidelines For Authors For Reviewers For Editors For Librarians For Publishers For Societies Article Processing Charges Open Access Policy Institutional Open Access Program Editorial Process English Editing Service MDPI Blog Initiatives Sciforum Preprints Scilit MDPI Books Encyclopedia About Login Register Submit Title / Keyword Author / Affiliation Journal Article Type Advanced Advanced IMPACT FACTOR 3.687 Volume 20, Issue 7 ►Article MenuViews Downloads No citations found yet Metrics0 Article Versions Abstract Full-Text PDF[1750 KB] Full-Text HTML Full-Text XML Full-Text Epub Article Versions Notes Related Info Google Scholar Order Reprints More by Authors on DOAJ on Google Scholar on PubMed Export Article BibTeX EndNote RIS Create a SciFeed alert for new publications With following keywords hepatocellular carcinoma (HCC) fibrosis cancer-associated fibroblasts (CAFs) hepatic stellate cells (HSCs) tumor microenvironment By following authors Jacopo Baglieri David A. Brenner Tatiana Kisseleva Advanced optionsEmail: Freq: One email with all search results One email for each search Renew × MOL Viewer × Open Access Review Int. J. Mol. Sci. 2019, 20(7), 1723; https://doi.org/10.3390/ijms20071723 (registering DOI) The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma Jacopo Baglieri1,*,David A. Brenner1,* andTatiana Kisseleva2,* 1 Department of Medicine, UC San Diego, La Jolla, CA 92093, USA 2 Department of Surgery, UC San Diego, La Jolla, CA 92093, USA * Authors to whom correspondence should be addressed. Received: 4 March 2019 / Revised: 29 March 2019 / Accepted: 5 April 2019 / Published: 7 April 2019 (This article belongs to the Special Issue Links between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges) Full-Text   |   PDF[1750 KB, uploaded 7 April 2019]   |  Figures Abstract Hepatocellular carcinoma (HCC) is one of the most aggressive types of cancer and lacks effective therapeutic approaches. Most HCC develops in the setting of chronic liver injury, hepatic inflammation, and fibrosis. Hepatic stellate cells (HSCs) and cancer-associated fibroblasts (CAFs) are key players in liver fibrogenesis and hepatocarcinogenesis, respectively. CAFs, which probably derive from HSCs, activate into extracellular matrix (ECM)-producing myofibroblasts and crosstalk with cancer cells to affect tumor growth and invasion. In this review, we describe the different components which form the HCC premalignant microenvironment (PME) and the tumor microenvironment (TME), focusing on the liver fibrosis process and the biology of CAFs. We will describe the CAF-dependent mechanisms which have been suggested to promote hepatocarcinogenesis, such as the alteration of ECM, CAF-dependent production of cytokines and angiogenic factors, CAF-dependent reduction of immuno-surveillance, and CAF-dependent promotion of epithelial-mesenchymal transition (EMT). New knowledge of the fibrosis process and the role of CAFs in HCC may pave the way for new therapeutic strategies for liver cancer. View Full-Text Keywords:hepatocellular carcinoma (HCC); fibrosis; cancer-associated fibroblasts (CAFs); hepatic stellate cells (HSCs); tumor microenvironment ▼ Figures Figure 1 This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). Share & Cite This Article MDPI and ACS Style Baglieri, J.; Brenner, D.A.; Kisseleva, T. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. Int. J. Mol. Sci. 2019, 20, 1723. Show more citation formats Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here. Article Metrics Article Access Statistics Abstract views Pdf views Html views 1 [Return to top] Submit to IJMS Review for IJMS Edit a Special Issue Int. J. Mol. Sci. 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