It’s not clear why or how a lower amount of the active molecule of the psilocybin mushroom or other psychedelic substance would not have any mind altering effect. There is no reason to believe that the larger amount of the substance used the more the psychedelic effect. Just how that could happen is not clear. More post synaptic activity? More neurons activated? And how is it a dose lower than needed for psychedelic effect would have a therapeutic effect.
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