UIC researchers discover unique organ-specific signatures for endothelial cells

UIC researchers discover unique organ-specific signatures for endothelial cells

Blood vessels in women age quicker than men's Similar results were found for heart endothelial cells, which expressed the genes known to help heart muscle cells beat and pump blood. "We have had anecdotal descriptions that blood vessel cells function differently in each organ for some time, but newer genetic tools allowed us to perform a global analysis of thousands of genes in the blood vessels of these vital organs," Rehman said. Rehman said the results of this study can be used to inform the bioengineering of blood vessels that are specific to different organs and that the findings suggest there are untapped avenues for developing more targeted treatments. "Our findings provide organ-specific blood vessel 'ZIP codes' for the potential delivery of drugs to specific tissues," Rehman said. "Right now, most treatments for vascular disease target all blood vessels regardless of where they are. Imagine if we could develop more effective treatments to uniquely improve the function of blood vessels in the heart or the brain?" Rehman said that this research suggests that blood vessels may play previously unrecognized roles in some neurological diseases such as Alzheimer's disease and other forms of dementia because the brain's endothelial cells expressed genes involved in cognitive function. Source: Journal reference: Jambusaria, A., et al. (2020) Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation. eLife . doi.org/10.7554/eLife.51413 .



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