Researchers discover antibiotics with unique approach to attacking bacteria
The study was done by scientists from the University of Melbourne and the University of California, Berkeley, who identified 351 different huge phages, all with genomes four or more times larger than the average genomes of viruses that prey on bacteria.
Among the discovery was the largest bacteriophage to date: its genome, 735,000 base-pairs long, is nearly 15 times larger than the average phage. This largest known phage genome is much larger than genomes of many bacteria.
"We are exploring Earth's microbiomes and sometimes unexpected things turn up," said Professor Jill Banfield, the senior author of the findings now published in Nature . "These viruses of bacteria are a part of biology, of replicating entities, that we know very little about."
Professor Banfield is now at Berkeley in earth and planetary science and environmental science, policy and management but did a significant portion of her work on the phages when she was in the School of Earth Sciences at the University of Melbourne.
These huge phages bridge the gap between non-living bacteriophage, on the one hand, and bacteria and Archaea (the diversity of bacteria). There definitely seems to be successful strategies of existence that are hybrids between what we think of as traditional viruses and traditional living organisms." Professor Jill Banfield
The new findings also have implications for human disease. Viruses in general carry genes between cells, including genes that confer resistance to antibiotics. And since phages occur wherever bacteria and Archaea live, including the human gut microbiome, they can carry damaging genes into the bacteria that colonize humans.
"Some diseases are caused indirectly by phages, because phages move around genes involved in pathogenesis and antibiotic resistance," said Professor Banfield. "And the larger the genome, the larger capacity you have to move around those sorts of genes, and the higher the probability that you will be able to deliver undesirable genes to bacteria in human microbiomes."
Professor Banfield has been studying the diversity of bacteria for more than 15 years. Source:
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