Reviewed by Kate Anderton, B.Sc. (Editor) Feb 16 2020
Barth syndrome (BTHS) is a rare and life-threatening, X-linked genetic disorder that primarily affects males and is passed from mother to son; women who are carriers do not show symptoms of the disorder. Fifty percent of children born to a mother who is a carrier will inherit the defective gene, and all daughters born to an affected man will be carriers. BTHS is caused by a mutation in the tafazzin gene that results in decreased production of cardiolipin, an essential lipid for energy metabolism.
A team from Wayne State University, led by Miriam Greenberg, Ph.D., professor of biological sciences in the College of Liberal Arts and Sciences, recently received a grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health to work on potential new targets for treating Barth syndrome. The four-year, nearly $1.5 million award, "The role of cardiolipin in the TCA (tricarboxylic acid) cycle: Implications for Barth syndrome," aims to identify specific metabolites as candidates for new treatments for Barth syndrome and other cardiomyopathies. Related Stories
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