Kura Oncology : Identifies Farnesylated Proteins Associated with CXCL12 Expression, Potential Biomarker of Clinical Benefit from Tipifarnib in Lymphoma Indications | MarketScreener

Kura Oncology : Identifies Farnesylated Proteins Associated with CXCL12 Expression, Potential Biomarker of Clinical Benefit from Tipifarnib in Lymphoma Indications | MarketScreener

April 03, 2019 0 Comments

SAN DIEGO, April02, 2019(GLOBE NEWSWIRE) -- Kura Oncology, Inc. (Nasdaq: KURA), a clinical-stage biopharmaceutical company focused on the development of precision medicines for oncology, reported new findings regarding the mechanism of action of the Company’s lead drug candidate tipifarnib and its potential clinical applications. These findings are being presented today at the American Association for Cancer Research (AACR) Annual Meeting 2019 in Atlanta. A copy of the poster is available on...

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A Red Mitochondria-Targeted AIEgen for Visualizing H2S in Living Cells and Tumours - Analyst (RSC Publishing)

April 03, 2019 0 Comments

Hydrogen sulfide (H2S) exits in the cytosols and mitochondria of mammalian cells as a signaling molecule. The scientists have explored many important physiological functions of H2S, such as regulating vasodilator relaxation, protecting living cells avoiding damage. The measurement for H2S is necessary to explore in biological function of cells and tissues. Herein, we design and synthesize a new aggregation-induced emission luminogen (AIEgen) with more extent conjugate and more positive charge ba...

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Phosphate Rocks Market 2019 Witness Highest Growth In Near Future Leading Key Players PhosAgro, Solvay, The Mosaic, OCP, JPMC - openPR

April 03, 2019 0 Comments

Up Market Research added a new Phosphate Rocks Market research report for the period of 2019 – 2026. Report focuses on the major drivers and restraints providing analysis of the market share, segmentation, revenue forecasts and geographic regions of the market. Get Sample Copy Of This Report @ www.upmarketresearch.com/home/requested_sample/75743 The report contains 96 pages which highly exhibit on current market analysis scenario, upcoming as well as future opportunities, revenue growth, pric...

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Science: Evidence for link between ‘leaky gut’ and autoantibody production in HIV-positive patients

Science: Evidence for link between ‘leaky gut’ and autoantibody production in HIV-positive patients

April 03, 2019 0 Comments

Reportes de Audio viernes, diciembre 28th, 2018 02:24 pm GMT -3 Libertades condicionales: Bancada PC/PRO valora el avance contra de la impunidad de violadores a los... miércoles, julio 11th, 2018 05:06 pm GMT -3 Política: Jefa de Bancada Regionalista valoró rechazo de censura y acusó orquestación desde La Moned... ...

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ImmunoPrecise Launches DeepDisplay(™) Antibody Discovery Platform - ImmunoPrecise Launches Large-Scale Discovery Program with US Pharma Company - ImmunoPrecise Antibodies LTD

ImmunoPrecise Launches DeepDisplay(™) Antibody Discovery Platform - ImmunoPrecise Launches Large-Scale Discovery Program with US Pharma Company - ImmunoPrecise Antibodies LTD

April 03, 2019 0 Comments

VICTORIA, April 2,2019 / – IMMUNOPRECISE ANTIBODIES LTD. (the “Company” or “IPA”) (TSX VENTURE: IPA) (OTC PINK: IPATF) announces the expansion of their service offerings in therapeutic antibody discovery to select rare, fully human antibodies using DeepDisplay™, a combination of transgenic animal immunization and custom phage display antibody selection. ImmunoPrecise has launched, in response to a large-scale discovery program with an unnamed, US-based Pharma company, a powerful and unique platf...

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Live Cell Imaging Market Share, Size, Trends, Growth, Global Demand, Regional Overview and Forecast by 2023 | Finds MRFR

April 03, 2019 0 Comments

Global Live Cell Imaging Industry ReportForecast to 2023 is latest research report published by “Market Research Future”, which provides comprehensive information on Live Cell Imaging Market – Trends, Size, Share, Statistics with historic and forecast data to 2023. The live cell imaging market is eyeing for an impressive growth at a stupendous 9% CAGR during the forecast period (2018-2023). Live cell imaging simply put, is the utilization of time lapse microscopy for studying the living cells...

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Agenus Begins Dosing with Next-Gen Anti-CTLA4 Antibody | BioSpace

April 03, 2019 0 Comments

LEXINGTON, Mass., April 2, 2019 /PRNewswire/ -- Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with a pipeline of immune-modulating antibodies, cancer vaccines, adjuvants and adoptive cell therapies1, today announced that the first patient was dosed in the clinical trial of its next-generation anti-CTLA4 antibody (AGEN1181). AGEN1181, a novel ‘Fc engineered’ antibody with potential for enhanced anti-tumor functions, is specifically designed to boost cancer killing immune cells and deplet...

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Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity

Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity

April 03, 2019 0 Comments

Fully effective vaccines for complex infections must elicit a diverse repertoire of antibodies (humoral immunity) and CD8+ T-cell responses (cellular immunity). Here, we present a synthetic glyco-adjuvant named p(Man–TLR7), which, when conjugated to antigens, elicits robust humoral and cellular immunity. p(Man–TLR7) is a random copolymer composed of monomers that either target dendritic cells (DCs) via mannose-binding receptors or activate DCs via Toll-like receptor 7 (TLR7). Protein antigens ar...

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Cinnamaldehyde in Flavored E-Cigarette Liquids Temporarily Suppresses Bronchial Epithelial Cell Ciliary Motility by Dysregulation of Mitochondrial Function.

Cinnamaldehyde in Flavored E-Cigarette Liquids Temporarily Suppresses Bronchial Epithelial Cell Ciliary Motility by Dysregulation of Mitochondrial Function.

April 03, 2019 0 Comments

Aldehydes in cigarette smoke (CS) impair mitochondrial function and reduce ciliary beat frequency (CBF), leading to diminished mucociliary clearance (MCC). However, the effects of aldehyde e-cigarette flavorings on CBF is unknown. The purpose of this study was to investigate whether cinnamaldehyde, a flavoring agent commonly used in e-cigarettes, disrupts mitochondrial function and impairs CBF on well-differentiated human bronchial epithelial (hBE) cells. To this end, hBE cells were exposed to d...

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Computational characterization of the peptidome in transporter associated with antigen processing (TAP)-deficient cells

Computational characterization of the peptidome in transporter associated with antigen processing (TAP)-deficient cells

April 03, 2019 0 Comments

The transporter associated with antigen processing (TAP) is a key element of the major histocompatibility complex (MHC) class I antigen processing and presentation pathway. Nonfunctional TAP complexes impair the translocation of cytosol-derived proteolytic peptides to the endoplasmic reticulum lumen. This drastic reduction in the available peptide repertoire leads to a significant decrease in MHC class I cell surface expression. Using mass spectrometry, different studies have analyzed the cellul...

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Global Natural Protein Powder Market Analysis & Forecast Report, 2019-2023 - The Increase in the Number of Product Launches is a Major Driver - ResearchAndMarkets.com

Global Natural Protein Powder Market Analysis & Forecast Report, 2019-2023 - The Increase in the Number of Product Launches is a Major Driver - ResearchAndMarkets.com

April 03, 2019 0 Comments

The “Global Natural Protein Powder Market 2019-2023” report has been added to ResearchAndMarkets.com’s offering. The natural protein powder market will register a CAGR of over 8% by Consciousness of health and fitness is one of the primary factors driving the market As people are becoming more heath conscious, their concentration and the emphasis on maintaining a healthy and balanced diet, physical exercise, and active lifestyle have grown. This has intensified...

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Prenatal Exposure to Bisphenol A Disrupts Naturally Occurring Bimodal DNA Methylation at Proximal Promoter of fggy, an Obesity-Relevant Gene Encoding a Carbohydrate Kinase, in Gonadal White Adipose Tissues of CD-1 Mice.

Prenatal Exposure to Bisphenol A Disrupts Naturally Occurring Bimodal DNA Methylation at Proximal Promoter of fggy, an Obesity-Relevant Gene Encoding a Carbohydrate Kinase, in Gonadal White Adipose Tissues of CD-1 Mice.

April 03, 2019 0 Comments

Exposure of mammalian fetuses to endocrine disruptors can increase the risk of adult-onset diseases. We previously showed that exposure of mouse fetuses to bisphenol A (BPA) caused adult-onset obesity. To examine roles of epigenetic changes in this delayed toxicity, we determined the effects of fetal mouse exposure to BPA on genome-wide DNA methylation and messenger RNA (mRNA) expression in gonadal white adipose tissues (WATs) by deep sequencing, bisulfite pyrosequencing, and real-time quantitat...

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Distinct Effects of Royal Jelly on Human Endothelial Cells Under High Glucose Condition.

Distinct Effects of Royal Jelly on Human Endothelial Cells Under High Glucose Condition.

April 03, 2019 0 Comments

To assess different effects of royal Jelly in protecting the human endothelial cells from high glucose level, human umbilical vein endothelial cells were exposed to various concentrations of royal jelly, from 0.625 to 10 mg/mL, at the presence of 5 and 30 mM glucose contents over a course of 72 h. In addition to cell viability assessment by conventional MTT assay, we also analyzed the feature of stemness by expression of Sox-2 and CD133 factors. Moreover, fatty acid profile, the expression of au...

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Thymol improves barrier function and attenuates inflammatory responses in porcine intestinal epithelial cells during lipopolysaccharide (LPS)-induced inflammation.

Thymol improves barrier function and attenuates inflammatory responses in porcine intestinal epithelial cells during lipopolysaccharide (LPS)-induced inflammation.

April 03, 2019 0 Comments

It is well known that essential oil thymol exhibits antibacterial activity. The protective effects of thymol on pig intestine during inflammation is yet to be investigated. In this study, an in vitro lipopolysaccharide (LPS)-induced inflammation model using IPEC-J2 cells was established. Cells were pre-treated with thymol for 1 h and then exposed to LPS for various assays. Interleukin 8 (IL-8) secretion, the mRNA abundance of cytokines, reactive oxygen species (ROS), nutrient transporters, and t...

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Mitochondria: Vol. 2 Comic 1 | Daily Trojan

Mitochondria: Vol. 2 Comic 1 | Daily Trojan

April 03, 2019 0 Comments

Mitochondria: Vol. 2 Comic 1 | Daily Trojan Mitochondria: Vol. 2 Comic 1 | Daily Trojan Facebook Twitter Youtube Instagram Rss Mail News Campus City Crime Housing Speakers and Events Lifestyle Columns Film Food Literature Music Theatre Sports Baseball Basketball Football Golf Women’s Lacrosse Rowing Sa...

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Genome-Wide Methylation Analysis Identifies NOX4 and KDM5A as Key Regulators in Inhibiting Breast Cancer Cell Proliferation by Ginsenoside Rg3.

Genome-Wide Methylation Analysis Identifies NOX4 and KDM5A as Key Regulators in Inhibiting Breast Cancer Cell Proliferation by Ginsenoside Rg3.

April 03, 2019 0 Comments

Ginsenoside Rg3 is a key metabolite of ginseng and is known to inhibit cancer cell growth. However, the epigenetics of CpG methylation and its regulatory mechanism have yet to be determined. Genome-wide methylation analysis of MCF-7 breast cancer cells treated with Rg3 was performed to identify epigenetically regulated genes and pathways. The effect of Rg3 on apoptosis and cell proliferation was examined by a colony formation assay and a dye-based cell proliferation assay. The association betwee...

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20(s)-ginsenoside Rg3-loaded magnetic human serum albumin nanospheres applied to HeLa cervical cancer cells in vitro.

20(s)-ginsenoside Rg3-loaded magnetic human serum albumin nanospheres applied to HeLa cervical cancer cells in vitro.

April 03, 2019 0 Comments

20(s)-ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. However, due to its poor aqueous solubility and low oral bioavailability, the use of 20(s)-Rg3 is limited. This study aimed to explore a method of preparing nano-sized 20(s)-ginsenoside Rg3 particle named 20(s)-ginsenoside Rg3-loaded magnetic human serum albumin nanospheres (20(s)-Rg3/HSAMNP) to change dosage form to improve its aqueous solubility and bioavailability. 20(s)-Rg3/HSAMNP were prepared by the desolvat...

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Seroprevalence, cross antigenicity and circulation sphere of bat-borne hantaviruses revealed by serological and antigenic analyses

Seroprevalence, cross antigenicity and circulation sphere of bat-borne hantaviruses revealed by serological and antigenic analyses

April 03, 2019 0 Comments

http://orcid.org/0000-0002-5322-1435 http://orcid.org/0000-0002-2844-9673 http://orcid.org/0000-0001-7587-152X Lin Xu,  Jianmin Wu,  Qi Li,  Yamei Wei,  Zhizhou Tan,  Jianqiu Cai,  Huancheng Guo,  Ling’en Yang,  Xiaohong Huang,  Jing Chen Bats are newly identified reservoirs of hantaviruses (HVs) among which very divergent HVs have been ...

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Generating and Working with Drosophila Cell Cultures - Advanced Science News

Generating and Working with Drosophila Cell Cultures - Advanced Science News

April 03, 2019 0 Comments

The use of Drosophila cell cultures has positively impacted both fundamental and biomedical research. The most widely used cell lines—Schneider, Kc, the CNS and imaginal disc lines—continue to be the choice for many applications. To improve the state of Drosophila cell cultures, researchers from the Drosophila Genomics Resource Center, a NIH-funded repository for Drosophila DNA and cell line resources at the Indiana University Bloomington, review the current challenges and opportunities in this ...

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Synergy between probiotic Lactobacillus casei and milk to maintain barrier integrity of intestinal epithelial cells.

Synergy between probiotic Lactobacillus casei and milk to maintain barrier integrity of intestinal epithelial cells.

April 03, 2019 0 Comments

We hypothesized that Lactobacillus casei BL23 and milk work synergistically to prevent damage to epithelial barrier integrity induced by pro-inflammatory cytokines. To test this, barrier disruption was induced in polarized Caco-2 monolayers by sequential, basolateral treatment with IFN-γ and TNF-α. Apical application of either 25% v/v reconstituted skim milk (RSM) or Ultra High Temperature (UHT) milk (2% fat) prior to cytokine exposure reduced losses to transepithelial electrical resistance (TER...

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Mechanisms of synergistic neurotoxicity induced by two high risk pesticide residues - Chlorpyrifos and Carbofuran via oxidative stress.

Mechanisms of synergistic neurotoxicity induced by two high risk pesticide residues - Chlorpyrifos and Carbofuran via oxidative stress.

April 03, 2019 0 Comments

Multi-component pesticide residues, especially pesticide residues with synergistic toxicity, are a serious threat to food safety. With risk assessment, we found that Chlorpyrifos (CPF) and Carbofuran (CBF) are 2 pesticide residues with highest risk for Actinidia chinensis planch. The results showed CPF and CBF have a synergistic neurotoxicity on neural cell SK-N-SH. The toxicity was partly depending on oxidative stress (OS) and had effects on cell apoptosis and cell cycle arrest. Furthermore, th...

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Lymphocytes DNA damages and exposure to chlorpyrifos, deltamethrin, penconazole, copper oxicloride.

Lymphocytes DNA damages and exposure to chlorpyrifos, deltamethrin, penconazole, copper oxicloride.

April 03, 2019 0 Comments

PURPOSE:The evaluation of the association between different exposure to pesticides and different types of comet images among a group of 26 recruited subject. MATERIAL AND METHODS:We have recruited 26 subjects (farmers and not farmers). They were submitted to a blood drawing of 10 mL and a questionnaire was administered to investigate personal habits and work history. By means of the comet assay it was assessed the oxidative DNA damage of peripheral lymphocytes by pesticides in the exposed a...

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Vitamin C Prevents Hydrocortisone-Induced Injury in HMEC-1 through Promoting Bestrophin-3 Expression.

Vitamin C Prevents Hydrocortisone-Induced Injury in HMEC-1 through Promoting Bestrophin-3 Expression.

April 03, 2019 0 Comments

OBJECTIVE:To investigate the protective effects and underlying mechanisms of Vitamin C (VC) on hydrocortisone (HC)-induced cell injury in human microvascular endothelial cells (HMEC). METHODS:Cell viability was measured by CCK-8 assay and the expression of Best-3 was detected by Western blotting assay. The experiment was divided into normal control, HC injury group, VC treatment groups, HC + Best-3 siRNA group, HC + VC + Best-3 siRNA group, HC + pcDNA3.1 Best-3 group, and HC + VC + pcDNA3.1...

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Basic Cell Culture Protocols

Basic Cell Culture Protocols

April 03, 2019 0 Comments

Goal amount for this month: 30 USD, Received: 0 USD (0%) Download Basic Cell Culture Protocols inside Othersforums : Basic Cell Culture ProtocolsByCheryl D. Helgason (auth.), Cheryl D. Helgason, Cindy L. Miller (eds.) 2005 | 371 Pages ... Basic Cell Culture ProtocolsByCheryl D. Helgason (auth.), Cheryl D. Helgason, Cindy L. Miller (eds.) 2005 | 371 Pages | ISBN: 1588292843 | PDF | 29 MB In this fully revised edition of an established classic, expert researche...

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DNA Methylation and Cancer Therapy

DNA Methylation and Cancer Therapy

April 03, 2019 0 Comments

Goal amount for this month: 30 USD, Received: 0 USD (0%) Download DNA Methylation and Cancer Therapy inside Othersforums : DNA Methylation and Cancer TherapyByMoshe Szyf Ph.D. (auth.) 2005 | 239 Pages | ISBN: 030647848X | PDF | ... DNA Methylation and Cancer TherapyByMoshe Szyf Ph.D. (auth.) 2005 | 239 Pages | ISBN: 030647848X | PDF | 6 MB NA methylation has bewildered molecular biologists since Hotchkiss discovered it almost six decades ago (Hotchkiss RDJ. B...

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